
The Trump administration has terminated Moderna’s $590 million contract for avian flu vaccine development, signaling a significant shift in America’s pandemic preparedness strategy and raising questions about the future of mRNA technology in public health.
Key Takeaways
- The Department of Health and Human Services (HHS) has canceled a $590 million contract with Moderna for developing an H5N1 bird flu vaccine using mRNA technology.
- HHS cited concerns about the “under-tested nature of mRNA technology” and past safety issues as justification for the contract termination.
- Despite the cancellation, Moderna reported positive interim results from their Phase 1/2 study, with 97.8% of participants achieving protective antibody levels.
- The H5N1 virus has already spread to multiple dairy herds and poultry farms in the U.S., with 70 human cases reported.
- Critics warn the decision could leave Americans vulnerable in the event of a serious avian flu outbreak.
Trump Administration Prioritizes Safety Over Experimental Technology
In a decisive move reflecting the administration’s commitment to vaccine safety, HHS has terminated funding for Moderna’s experimental bird flu vaccine program. The contract, initially valued at $590 million, was part of a broader pandemic preparedness initiative but has now been canceled following what officials describe as a thorough scientific review. Despite Moderna reporting promising early results from their Phase 1/2 study, the administration determined that continuing investment in this particular mRNA-based approach did not meet the necessary benchmarks for taxpayer funding.
HHS Communications Director Andrew Nixon explained the rationale behind the decision, emphasizing the administration’s commitment to responsible health policy. “This is not simply about efficacy — it’s about safety, integrity, and trust. The reality is that mRNA technology remains under-tested, and we are not going to spend taxpayer dollars repeating the mistakes of the last administration, which concealed legitimate safety concerns from the public,” said Nixon.
Moderna Responds to Contract Termination
Despite the setback, Moderna remains optimistic about their avian flu vaccine program. The company announced that their Phase 1/2 study demonstrated strong results, with nearly 98% of participants developing protective antibody titers after receiving two doses of the experimental vaccine. The study, which included approximately 300 healthy adults, showed what the company described as a “robust immune response” with a favorable safety profile and generally mild adverse reactions that did not significantly increase with additional doses.
🚨#BREAKING MAHA 🇺🇸
Moderna OFFICIALLY Loses $700M US Contract for Bird Flu Vaccine Development!Moderna OFFICIALLY ANNOUNCES that the Trump administration has canceled a major contract worth nearly $700 million for the development of its bird flu vaccine.
This decision ends a… pic.twitter.com/esAEQeAMPK
— SANTINO (@MichaelSCollura) May 29, 2025
“While the termination of funding from HHS adds uncertainty, we are pleased by the robust immune response and safety profile observed in this interim analysis of the Phase 1/2 study of our H5 avian flu vaccine and we will explore alternative paths forward for the program,” said Stéphane Bancel Chief Executive Officer of Moderna
The company has indicated it will pursue alternative funding sources to continue development of the vaccine, underscoring their belief in mRNA technology as a platform for addressing pandemic threats. Bancel emphasized that despite the government’s decision, Moderna remains committed to advancing their influenza programs and building on their experience with previous mRNA-based vaccines.
Experts Divided on Potential Impact
The decision has prompted criticism from some public health experts who worry about America’s preparedness for a potential avian flu outbreak. The H5N1 virus has already been detected in multiple dairy herds and poultry farms across the United States, with approximately 70 human cases reported. Although the virus has not yet demonstrated efficient human-to-human transmission, experts remain concerned about the possibility of mutations that could increase transmissibility.
“After a rigorous review, we concluded that continued investment in Moderna’s H5N1 mRNA vaccine was not scientifically or ethically justifiable,” said HHS Communications Director Andrew Nixon
The United States does maintain a Strategic National Stockpile of H5 vaccines developed using conventional technology, which provides some level of protection against potential outbreaks. The Trump administration has indicated that future pandemic preparedness investments will focus on vaccine platforms with more established safety profiles and transparent data practices, reflecting a broader commitment to ensuring Americans have access to vaccines they can trust without sacrificing safety for speed of development.
Financial Implications and Future Direction
For Moderna, the loss of this contract represents a significant financial setback, though the company continues to advance several other vaccine programs across its portfolio. The decision may signal a larger shift in how government health agencies evaluate and fund vaccine development under the Trump administration, with increased scrutiny being applied to newer technologies that haven’t undergone the same level of long-term safety monitoring as traditional approaches.
As the government redirects funding toward alternative pandemic preparedness strategies, questions remain about the optimal balance between innovation and established technologies in preparing for future health threats. The administration has emphasized that this decision reflects a commitment to responsible stewardship of taxpayer dollars and ensuring that public health investments deliver maximum benefit with minimal risk to the American people.